Xi'an RyonBio Biotechnology Co., Ltd.

Acetaminophen raw material, is an organic compound with the chemical formula C8H9NO2. It is a metabolite of phenacetin in the body. It reduces the synthesis of prostaglandin PGE1, bradykinin and histamine by inhibiting prostaglandin synthase in the hypothalamic thermoregulatory center. and release. PGE1 mainly acts on the nerve center. Its reduction will cause the central body temperature set point to drop, and the body surface temperature receptors will feel relatively hot. This will then cause peripheral blood vessels to dilate and sweat through neural regulation to achieve an antipyretic effect, which inhibits the central nervous system. The effects of prostaglandin synthesis are similar to those of aspirin, but their anti-inflammatory effects are weaker. It has no effect on platelets and coagulation mechanism.

Reduces fever and pain relief: It works by blocking the effects of chemicals in the body that cause pain and inflammation. The drug is very effective and has a wide range of applications. It can be used to treat headaches, colds, flu, arthritis, toothache, menstrual cramps, and other types of pain. One of its biggest advantages is its security. Unlike other pain relievers such as aspirin and ibuprofen, it does not irritate the stomach or cause stomach bleeding. This is a good option for people with stomach problems or who are taking blood thinners. It is also safe for children and pregnant women when used as directed.

In addition to its pain-relieving and fever-reducing properties, it also has several other potential health benefits. Recent research suggests it may have anti-inflammatory properties and could be used to treat conditions such as osteoarthritis and rheumatoid arthritis. It has also been shown to be effective in reducing the symptoms of chronic low back pain.

There are some potential risks with using acetaminophen, especially when the drug is taken in high doses or for a long time. Overdosage can cause liver damage, so it is important to follow dosing instructions carefully. People who drink regularly or have liver problems should use it with special caution.

Should be stored in a cool, dry, well-ventilated place. The temperature should be kept at 25°C or below, and the humidity should be kept below 60% to prevent moisture absorption and protect the active ingredients from degradation. Exposure to high humidity can cause it to break down and reduce its effectiveness. Therefore, it is also important to avoid storing raw materials in areas with high humidity, such as bathrooms or kitchens.

It should be stored away from direct sunlight and other heat sources such as stoves or ovens. This is because exposure to heat and light can also accelerate the degradation of active ingredients and reduce the overall effectiveness of the product. Additionally, prolonged exposure to sunlight may cause discoloration and change its appearance.

It’s also important to keep it away from children and pets. Raw materials should be stored in a safe location out of the reach of children or pets as they may be toxic if ingested in large amounts.

The two drugs have similar antipyretic effects, but a single dose of acetaminophen has a faster onset of action, while ibuprofen has a relatively strong antipyretic effect and maintains cooling for a relatively long time. In terms of anti-inflammatory, acetaminophen has no anti-inflammatory effect, while ibuprofen has anti-inflammatory effect. Therefore, acetaminophen cannot replace ibuprofen, etoricoxib and other drugs in the treatment of rheumatoid arthritis and gouty joints. inflammation. In terms of analgesic effect, acetaminophen is suitable for headaches, while ibuprofen is more suitable for menstrual pain and abdominal cramps.

1. It is recommended that the maximum oral dose of acetaminophen per day should not exceed 2 grams. If you take 6 to 10 grams at a time, it can cause extensive liver tissue necrosis and even liver failure. Signs of liver damage after overdose include: nausea, loss of appetite, sweating, extreme fatigue, pain in the right upper quadrant, unusual bleeding and bruising, cold symptoms, yellowing of the eyes or skin, and vomiting. Once overdose is discovered or symptoms of overdose occur, the drug should be stopped immediately and seek medical attention. Timely treatment can reduce damage and protect the liver.

2. When taking compound cold medicines, be sure to read the drug instructions carefully and check the ingredients of the medicines, and avoid taking medicines containing acetaminophen or other medicines containing antipyretic and analgesics at the same time, otherwise it is easy to cause overdose or accumulation of medicines. Adverse drug reactions.

3. While taking acetaminophen, do not drink alcohol or alcoholic beverages; it should not be used for more than 3 consecutive days when used for antipyretic treatment, and should not be used for more than 5 consecutive days when used for pain relief.